The CADASIL Consortium sends all blood samples to the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD). The overall goal is to support research focused on the causes, early detection, and treatment development for Alzheimer’s Disease and Related Dementias (ADRD), such as CADASIL. NCRAD is a national resource where clinical information and biological materials, such as DNA, plasma, serum, RNA, cerebrospinal fluid, cell lines, and brain tissue can be stored and then used for research to advance the care and cure of persons with dementia. NCRAD currently maintains samples from multiple individuals with ADRD as well as healthy controls. For more than 30 years, NCRAD has been a key resource to support ADRD research. NCRAD’s mission focuses on the standardization and best practices for sample collection, storage, distribution, and processing. NCRAD’s success is driven by the use of standard operating procedures to ensure uniformity and to minimize the impact of preanalytical variables on downstream sample analyses.