The CADASIL Consortium strives to identify the biological and clinical markers in order to inform basic science research and clinical care with the hope of generating information that can be used to design treatment studies

Our research team is dedicated to finding ways to intervene in the CADASIL trajectory and to study interactions with risk factors impacting the aging life course. We are actively seeking persons who were at risk but who tested negative (non-carriers of the NOTCH3 gene mutation) in order to characterize the presentation of CADASIL with family members. Participants who have tested negative are critical in order to clarify genetic, health, and lifestyle factors which impact clinically meaningful outcomes in CADASIL..